IPAK-EDU

Systems Biology and Human Health

Store/Biology Curriculum Track

Product Details

Systems Biology and Human Health

Dr. James Lyons-Weiler

Spring, 2025

This course offers an immersive exploration into the intricate world of systems biology, specifically tailored to uncover the deep interconnectedness between complex biological pathways and their profound impact on human biology, health and disease. Designed for a diverse audience, from students to professionals in the field, this curriculum begins with foundational insights into biological pathways, advancing through critical topics such as signal transduction, cellular metabolism, genetic regulation, and the dynamic interactions within the microbiome, immune, and endocrine systems. With a focus on real-world applications, the course delves into the complexities of cancer biology, the principles of toxicology, and the latest research in neuroendocrine systems and chronic disease mechanisms. This comprehensive program not only aims to enrich understanding but also to inspire innovative approaches to biomedical challenges, making it an essential journey for anyone looking to deepen their knowledge and impact in the realms of health and medicine.

Lecture 1: Course Overview

Introduction to systems biology, course goals, structure, and key concepts.

Lecture 2: Decoding Biological Pathways

Fundamental tools and methodologies for mapping and interpreting biological pathways.

Lecture 3: Signal Transduction Pathways

The mechanics of cellular communication and response to external signals, focusing on major pathways like G-protein coupled receptors.

Lecture 4: Cellular Metabolism and Energy Dynamics

Exploration of central metabolic pathways, their regulation, and impact on cellular function.

Lecture 5: Genetic Networks and Epigenetics

Understanding the regulatory networks that control gene expression and how epigenetic changes affect these processes.

Lecture 6: Microbiome and Human Health

Examining the complex interactions between the microbiome and host health, including impacts on disease and wellness.

Lecture 7: Immune System Dynamics

Detailed exploration of the immune system's complexity, focusing on its regulation and role in health and disease.

Lecture 8: Endocrine System and Hormonal Regulation

Delving into the complexities of the endocrine system, emphasizing feedback mechanisms and disease implications.

Lecture 9: Neuroendocrine Systems

Exploring the interaction between the nervous and endocrine systems and their combined impact on physiological and behavioral processes.

Lecture 10: Cancer Biology: Pathways to Tumorigenesis

Investigating cellular and molecular pathways leading to cancer, with emphasis on systems biology approaches to understanding and treatment.

Lecture 11: Dynamics of Toxicology

Understanding how toxic substances interact with biological systems, including mechanisms of action, detoxification, and implications for human health.

Lecture 13: Pathophysiology of Metabolic Syndrome

An in-depth look at the complex interactions leading to metabolic syndrome, including obesity, insulin resistance, and cardiovascular risk.

Lecture 14: Neurodevelop and Systems Neurobiology

Examining the complexity of developing neural systems, from synaptic function to neural circuits, and their role in cognition and disease.

Lecture 15: Autoimmunity and Complex Diseases

Investigating the multifactorial origins of autoimmune diseases, incorporating genetic, environmental, and immune system interactions.

Lecture 17: Dysautonomia: Understanding Autonomic Nervous System Disorders

This lecture delves into the complexities of dysautonomia, a term used to describe disorders of the autonomic nervous system (ANS), which controls the body's involuntary functions, including heart rate, blood pressure, digestion, and temperature regulation. Participants will explore the fundamental mechanisms of the ANS, its role in maintaining homeostasis, and how dysregulation can lead to a wide array of clinical manifestations, ranging from mild symptoms to life-altering conditions. Through examining the etiology, diagnosis, and management strategies for various forms of dysautonomia, such as Postural Orthostatic Tachycardia Syndrome (POTS) and Autonomic Neuropathy, the lecture aims to provide a comprehensive understanding of these conditions, highlighting the importance of the ANS in overall health and the challenges faced in treating dysautonomia. This addition enriches the course's exploration of complex systems in health, offering insights into the interplay between neurological function and systemic health.

Lecture 16: Integrative Approaches to Chronic Diseases

Focusing on the systems biology approach to understanding and managing chronic diseases, emphasizing holistic and integrative treatment strategies.

JOIN US as we embark on a profound journey into the heart of systems biology and its pivotal role in understanding human health and disease with our course. This meticulously structured program is designed to illuminate the complex biological processes that underpin health, disease, and the therapeutic interventions that hold the potential to transform patient care. Perfect for students, professionals, and anyone with a keen interest in the cutting-edge intersection of biology and medicine, this course offers:

- A Solid Foundation: Begin with the essentials of reading and understanding biological pathways, setting the stage for all subsequent learning.

- In-Depth Exploration: Delve into the intricacies of signal transduction pathways, cellular metabolism, and the regulatory landscapes of genetics and epigenetics, providing a comprehensive understanding of cellular function and regulation.

- Specialized Topics: Navigate through the complex interactions within the microbiome and its impact on human health, alongside a detailed examination of the immune and endocrine systems, emphasizing their roles in maintaining health and contributing to disease.

- Advanced Insights: Unpack the complexities of cancer biology, exploring the cellular and molecular pathways that lead to tumorigenesis, and delve into the dynamics of toxicology to understand how substances interact with biological systems.

- Cutting-Edge Themes: Additional lectures cover the neuroendocrine system, the challenges of metabolic syndrome, systems neurobiology, and the multifaceted nature of autoimmune and chronic diseases, offering advanced insights into current and emerging issues in health and medicine.

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